2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2227
    Leucyltyrosine 968-21-8 98%
    Leucyltyrosine is an ACE inhibitor (IC50s: 44 μM (HHL as substrate) and 534 μM (HPA as substrate)).
    Leucyltyrosine
  • HY-P2366
    Teprotide 35115-60-7 98%
    Teprotide is an inhibitor of angiotensin-converting enzyme (ACE) inhibitor. Teprotide can be used to study hypertensive.
    Teprotide
  • HY-P2496
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled 98%
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled is an Endothelin-1 conjugated with Alexa Fluor 488 (HY-D1304). Endothelin-1 is an endogenous vasoconstrictor and agonist of ETA/ETB receptor. Endothelin 1 (swine, human) exerts effects including promoting mitosis, angiogenesis, tumor invasion and metastasis, and inhibiting apoptosis. Endothelin 1 (swine, human) induces inflammation and oxidative stress by activating the NF-κB pathway. Endothelin 1 (swine, human), Alexa Fluor 488-labeled is specifically designed for fluorescence imaging, flow cytometry or receptor localization studies, and can be used in research related to sepsis, atherosclerosis, systemic inflammatory response syndrome, cancer and congestive heart failure.
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled
  • HY-P2539
    Big Endothelin-1 (1-39), porcine 120796-99-8 98%
    Big Endothelin-1 (1-39), porcine is the precursor of endothelin-1. Endothelin-1 (ET-1) is a potent vasopressor peptide. Big Endothelin-1 (1-39), porcine has similar pressor effects in vivo.
    Big Endothelin-1 (1-39), porcine
  • HY-P2595
    SKF 103784 111372-60-2 98%
    SKF 103784 is an vasopressin antagonist with activity against vasopressin. SKF 103784 inhibits the physiological response caused by antidiuretic and is therefore used to study biological processes related to water and salt balance. SKF 103784 can also be used to explore pathological mechanisms related to cardiovascular diseases and endocrine dysfunction.
    SKF 103784
  • HY-P2619
    BPP 5a 30505-63-6 98%
    BPP 5a is a bradykinin-potentiating peptide with vasorelaxant activity, which is found in Bothrops jararaca venom. BPP 5a is an angiotensin-converting enzyme (ACE) inhibitor with a Ki value of 400 nM. BPP 5a is promising for research of hypertension and cardiovascular diseases.
    BPP 5a
  • HY-P2643
    Angiotensin I/II (4-8) 52530-60-6 98%
    Angiotensin I/II (4-8), a major metabolite of Angiotensin II, is a C-terminal 4-8 pentapeptide.
    Angiotensin I/II (4-8)
  • HY-P2687
    Ularitide 118812-69-4 98%
    Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure.
    Ularitide
  • HY-P2696
    EP 80317 268545-47-7 98%
    EP 80317 is a selective CD36 ligand. EP 80317 protects the heart against damage and dysfunction elicited by myocardial ischaemia and reperfusion (MI/R), along with a transient reduction in peripheral lipolysis. EP 80317 can be used for the study of cardiovascular disease.
    EP 80317
  • HY-P2708
    H-Gly-Pro-Arg-Pro-NH2 126047-75-4 98%
    H-Gly-Pro-Arg-Pro-NH2 is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein. H-Gly-Pro-Arg-Pro-NH2 prevents fibrin polymerization.
    H-Gly-Pro-Arg-Pro-NH2
  • HY-P2712
    Chemerin-9, mouse 686324-96-9 98%
    Chemerin-9, mouse (Chemerin148-156, mouse) is a C-terminal nonapeptide of chemerin. Chemerin-9, mouse is a ligand for ChemR23 (EC50 = 42 nM). Chemerin-9, mouse reduces basal lipolysis in primary mouse white adipocytes(IC50 = 3.3 nM). Chemerin-9, mouse enhances memory and relieves Aβ1-42-induced memory impairment in AD mice. Chemerin-9, mouse also inhibits atherogenesis.
    Chemerin-9, mouse
  • HY-P2749
    Glutamine synthetase 9023-70-5 98%
    Glutamine synthetase is an enzyme that converts glutamate and ammonia into glutamine. Glutamine synthetase can inhibit angiogenesis in ocular and inflammatory skin diseases. Glutamine synthetase can also palmitoylate RHOJ, thereby inhibiting endothelial cell migration. Glutamine synthetase can be used in research on various diseases, including cardiovascular and cerebrovascular diseases and cancer.
    Glutamine synthetase
  • HY-P2763
    beta-Glucanase 9074-98-0 98%
    beta-Glucanase belongs to glycosyl hydrolase family that hydrolyzes β-glucan polysaccharide, producing 3-O-cellotriosyl-d-glucose and 3-O-cellobiosyl-d-glucose. beta-Glucanase is capable of protecting plants against different fungal pathogens.
    beta-Glucanase
  • HY-P2781
    3′,5′-Cyclic nucleotide phosphodiesterase 9040-59-9 98%
    3′,5′-Cyclic nucleotide phosphodiesterase is a hydrolytic enzyme that degrades cyclic 3', 5' -adenosine monophosphate (cyclic AMP). 3′,5′-Cyclic nucleotide phosphodiesterase is promising for research of cardiovascular diseases, inflammation, central nervous system disorders, and metabolic syndrome.
    3′,5′-Cyclic nucleotide phosphodiesterase
  • HY-P2916
    Thymidine phosphorylase 9030-23-3
    Thymidine phosphorylase is a nucleoside metabolism enzyme that plays an important role in the pyrimidine salvage pathway. Thymidine phosphorylase catalyzes the conversion of thymidine to thymine and 2-deoxy-α-D-ribose-1-phosphate (dRib-1-P). Thymidine phosphorylase plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Thymidine phosphorylase can be used for the study of myocardial infarction, stroke, pulmonary embolism and cancer.
    Thymidine phosphorylase
  • HY-P2927
    Protein disulfide isomerase 37318-49-3 98%
    Protein disulfide isomerase is a prototypic thiol isomerase that catalyzes the formation and cleavage of thiol-disulfide bonds during protein folding in the endoplasmic reticulum (ER). Protein disulfide isomerase can be used for the study of cardiovascular diseases.
    Protein disulfide isomerase
  • HY-P3006
    Des-Leu10-angiotensin I 34273-12-6 98%
    Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a Ki value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell.
    Des-Leu10-angiotensin I
  • HY-P3050
    Helospectin II 93585-83-2 98%
    Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.
    Helospectin II
  • HY-P3053
    Helospectin I 93438-37-0 98%
    Helospectin I is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin I has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin I is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.
    Helospectin I
  • HY-P3054
    S6 peptide 93674-74-9 98%
    S6 peptide is a potentially important lamin kinase. S6 peptide is involved in the process of cardiac hypertrophy induced by mechanical loading. S6 peptide can be activated by many kinds of growth factors.
    S6 peptide
Cat. No. Product Name / Synonyms Application Reactivity